Like GRJ said, yes. If you use two different capacities then you will be able to create a RAID 1 of the lowest capacity drive. I beleive the extra space is not usable in this situation.
I too was running two 1TB drives, one from WD and the other Samsung (my favorite). I ended up buying another Samsung drive and the WD is not sitting on a shelf waiting for some other project.
Just something to note, you do not need a fast hard drive for this NAS. If you are going to buy a new drive specifically for this NAS, buy an ECO drive or something with a slow spin rate, low heat. This NAS does not benefit from the faster drives due to it's inherently slow electronics. It's an entry level NAS so I can't complain.
-Joe