I'm not aware of any issues relating to the size of the drive's cache memory - there is one that relates to the "sector" size - older drives used 512 byte sectors, newer ones with AFT (Advanced Format Technology) use a 4K sector size - and these require the 1.10 firmware to format properly.
AFT was implemented to resolves space/addressing issue - with 512 byte sectors, it takes a larger allocation bitmap (or file allocation table) to handle a given storage capacity, using a 4K sector size reduces the size of the required bitmap by a factor of eight.
Assuming that the 6Gb/s drives are backward compatible, I see no reason why they should not work, but, what you can be assured of is that there will be no throughput advantage to their use.