Yes, I have two laptops and both run Vista. One of the two is a dual-boot system, so I can run XP also.
Performance seems to be about the same regardless of the laptop or OS, which is why I started wondering if it was related to the network itself.
I have disabled autotuning on Vista, and didn't notice much difference. I have not attempted to change any of the wireless or wired network card parameters via device manager though. I didn't see any obvious looking options when I checked them out.