Technically speaking, a jumbo frame is anything over the standard 1514, the most common (in my experience) are 4000 & 9000.
The end points in a jumbo frame connection will negotiate a maximum segment size (MSS) that is acceptable to both, but any network devices in between are not a part of this negotiation, so if you configure a frame size that is acceptable to both, but larger than the switch can handle, the connection will fail, and in my experience, it will be extremely slow rather than timing out completely and reporting an error.
If you change either end to a smaller segment size, in this case, the computer end is being set to a regular (ie non jumbo) frame, the MSS acceptable to both becomes 1514, and the switch passes it.
If you drop the computer end to 4514, the DNS-323 will auto-negotiate an MSS of 4514, and if the switch can accomodate it, jumbo frame communications will occur, if not, it'll fail again.
You can try this quite easily and also verify the switch as being the problem - just set static ip addresses and then hardwire the DNS-323 directly to the computer.