It should work fine. At least it has for numerous others. Actually, you can use several 4TB drives also for a total of 8TB. I have used the Red 3TB but have gone to 4TB Hitachi's. Sometimes people have issues with the initial format. If so, I have had the best luck with raw drives. If you already formatted them and have trouble, just put them in a Windows machine or whatever and delete all the volumes and partitions. good Luck.