Here is how to fix “This Publisher has been Blocked from Running Software on your Machine” In Windows 10
1- Let’s say the setup file of the application that gives the This Publisher has been Blocked from Running Software on your Machine error is in the E drive as shown in the following screenshot. To be precise, it is located at the path: E:\Set up files\aida64extreme280.exe.
2- Open the Command Prompt in the administrator mode. For that, start typing in cmd to windows search box. When the Command Prompt appears in the search results, right click on it and choose Run As Administrator option.
3- As next, you have to navigate to the location of the setup file which is being blocked.
4- There you are! Now your installation setup would open without any issue.
Source:-
https://merabheja.com/fixed-publisher-blocked-running-software-machine-windows-10/