I am not sure if my comments will help, but they are better than nothing.
There is much less support for OS X that there is for Windows systems. I have a 10.6.8 system and use the DNS-323 for backup only. The disks on the 323 are formatted as Standard and I use SuperDuper to back my system twice, once to each disk as incremental backups. SuperDuper creates sparse image files so samba is not an issue.
I like FireFox better than Safari for the web interface, but I had some problems determining the ip address that was assigned. It would be nice if there was a version of the Easy Search Utility for OS X.
Also try searching the forum for Lion + 323.