DNS-321 is the ftp server, the computer (or other device) you are uploading from or downloading to is the ftp client.
The term client side issue is used to indicate that the problem is cause by something at the client side of the connection.
ftp transfers are different (I'm inclined to say unique) from others (eg. http, telnet, etc.) in that they use two distinctly separate connections, a control connection and a data connection (in contrast, http etc. use a single connection, or series of connections, from the client to the server). With active ftp, the control connection is established from the client to the server and the data connection is established from the server to the client - the problem with this is consumer type NAT firewall/routers, by default allow outgoing connections (established from the inside) and block all incoming connections (established from the outside).
Most consumer type NAT firewall/routers are smart enough to know that an outgoing connection on port 21 to ip address a.b.c.d is ftp, and so they will look for an incoming connection from ip address a.b.c.d and allow it through, forwarding it to the appropriate host - BUT - they don't recognise that your connection on port 2121 (or whatever you use) is ftp, so when the server tries to establish the data connection, they block it.
Because of this, passive ftp was developed - with passive ftp the client establishes a control connection on whatever port (default is 21) - and the server tells it to establish the data connection on a specific port, so, since the data connection is established from the client to the server, this removes the client side issue - BUT - if the server is also behind a consumer type NAT firewall/router, this results in a server side issue.
Passive ftp shifts the problem from the client side to the server side, but, since most ftp servers are commercial installations, with certified administrators, and one server might accomodate a few thousand (or hundred thousand) clients, the overall result is that things are generally made easier for the larger number of people.
With passive ftp, if the ftp server is behind a consumer type NAT firewall/router, you would need to forward, not just the port for the control connection, but also a range of ports for the data connection, and this is what the DNS-321 is lacking - there is no way for you to tell it that you are going to forward, for example, ports 21000~21100 for passive ftp.
You cannot properly configure passive ftp on the DNS-321 - but - if your ftp client is using active ftp and is not behind a NAT firewall/router, active ftp on a non-standard port (one other than 21) will work because there will be no problem with the data connection being blocked.