I tried again last night. With 1.21, I could download a movie trailer. I upgraded to 1.22 (I always do my settings from scratch) and movie trailers would kill the networking on that computer. I downgraded to 1.21 and could download movie trailers.
In a system with three components like this (computer -- router -- internet), debugging a problem should always start with "what changed". Did the computer get an update? Did the ISP have an outage? Did a DNS die?
In my situation, the router firmware was the only change. All router settings except WPA & the admin password are the same.
Why don't you have a problem downloading large files? Maybe you're using ftp & Front Row is using sftp. Maybe your computer is closer to the router. Maybe your network card isn't a broadcom based Airport Extreme.
There's definitely a connection between 1.22 and the problem. It's repeatable. It could be that 1.22 triggers a bug in that broadcom card. It could be that 1.22 doesn't like an 802.11n computer to be too far away when initiating a large download. I don't know the exact cause.
But, it would be interesting to know what changed between 1.21 and 1.22 to see if it could affect this. If they made no such changes, then I'd start attacking the Mini to see if it has a problem.
Since 1.21 works fine, though, I have no reason to go to 1.22... (but can't wait for 1.30!!!)