As nobody replied until now, I like to post my own experience on progressing to backup a 3TB HDD to USB drive:
I could not use my 3TByte Intenso Memory Center, formatted with NTFS or exFAT, as a USB backup drive on the DNS-320L.
Originally it was formatted with FAT32 (however this is done - so far beyond FAT32 specs...), but this restricts maximum file size to <4GByte.
The only way of making use of this nice drive is to connect it to a PC and simply copy files through Windows from the network shares to the USB disk.
If anybody ever had a >2TByte USB disk running directly on the DNS-320L, please give me a note.thx, folks! And good luck to everybody trying the same.