Based partly on this post and other searches I also decided to upgrade my DNS-323 (A1) to two of these 2TB ST2000DM001 drives. I thought it was slightly risky (I could not find any 2TB drives currently on the market guaranteed to work), but knew I had other uses for these drives if they proved not to work.
My findings so far:
The guidance about using 4K drives in the DNS-323 says they will fail to format unless on the 1.10 firmware, so I duly upgraded from 1.09 and formatted them as two individual disks (no RAID) in EXT2 mode.
Both formatted fine, but the immediate issue I had was transfer speed. Neither disk would copy files any faster than 2MB/s and they would frequently "stutter" or "stall" where the speed would drop to 0 for up to around 20 seconds.
So I downgraded to 1.09 and tried formatting again. Once again the formatter appeared to complete OK (it took a long time), but I had exactly the same issues with transfer speeds.
Finally I tried the Alt-F firmware (EXT4 mode) and immediately transfer speeds were back up to 10MB/s (the max speed for my 10/100 network). With great relief I now have a 4TB DNS-323 that so far seems completely stable...
The differences between BKozan's experience and mine is the use of the 1.08 firmware (which - like 1.09 - in theory shouldn't work); the use of RAID EXT3 (would this matter?); and the revision B1 of the device (perhaps this is key?).