Actually there's no way we can answer that since we don't know anything about the rest of your network.
My suggestion would be that you leave it the speed/duplex on auto, and unless you have a network with a gigabit switch, that supports jumbo frame, and your computer(s) also support jumbo frame, that you leave jumbo frame disabled.
If your does support jumbo frame, then enable it and test throughput with the different frame sizes - what works best on my network may not be best on yours.
By the way - since your question displays an incredible amount of naivety - get a good book on ethernet networking (or use google) and learn what the terms mean and how things work - before trying to tweak them for greater throughput.