I do have some personal experience garnered over the roughly six years I owned a DNS-323, it's still sitting on a shelf behind me, even though it no longer boots (either corrupt firmware or failed hardware) - I did have at least one, "live" disk failure, but before actually deploying the unit, I spent a number of weeks, simulating various scenarios, which included inserting "known defective" disks, to see if the unit would detect them as defective (it rarely did) and also "hot unplugging" disks to test RAID rebuilds.
Alas, those tests showed the unit was not ready for "prime time", which disappointed me immensely as I had a number of SOHO clients who could have benefitted from it.